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Remanufactured transmissions that fit the 2006 Lexus Is350. Each unit below is matched to this vehicle, warranty-backed, and shipped with freight quoted at checkout from Peak Powertrain.
Rule of thumb: a transmission replacement is usually worth it when the installed cost stays under 40% of what the 2006 Lexus Is350 is worth — most units below beat that comfortably.
As a general rule of thumb, a transmission replacement on a 2006 Lexus Is350 (luxury segment, vehicle value roughly $6,000–$6,720) is usually worth it when the installed cost stays under about $2,400 — roughly 40% of what the vehicle is worth.
Based on vendor-verified fitment data across 7 listed transmissions, remanufactured and new transmissions for this model cover the 2006–2019 model years. Always confirm your exact VIN or engine/transmission code before ordering, since fitment can vary by submodel or engine.
